Emer-G-Med currently had multiple Advanced Life Support response vehicles and ambulances at the scene. Many people have been hurt with some being hurled onto the south bound lanes on the N1 South between Allandale Road and the Buccleuch Interchange in Midrand.
Paramedics arrived on the scene at 10:18 am to find that a taxi had rolled after the driver lost control when a tyre burst.
One patient has been declared dead on the scene.
Paramedics worked to stabilise the injured, some of which were in a critical condition.
One critically injured patient was airlifted to a specialist trauma hospital.